 |
Lillian Waldbeser, Ph.D.
Associate Professor of Biology and Biomedical Sciences
|
Education
-
B.S. University of Hawaii
-
M.S. California State University, Dominguez Hills
-
Ph.D. Oregon Health Sciences University
Research Interests
Studies involve microbiology, recombinant DNA, protein analysis, cell biology (apotosis, necrosis, signal transduction and intracellular trafficking), and immunology (phagocytosis, cytokines and adhesion molecules).
The focus of my laboratory is on molecular mechanisms of pathogenesis of Neisseria meningitidis, a bacterium that causes bacteremia with or without meningitis and has a 25 % mortality rate even if treated. The rapid onset of the disease, the fulminant course of the infection in some individuals, and the high mortality rate in the absence of immediate antimicrobial treatment, are the reasons for the profound impact of this infection. The laboratory is studying how this bacterium is able to survive the phagocytic killing inside phagocytes such as macrophages.
RESEARCH GRANTS
- 1997 NSF-ILI grant
- 1997 Texas A&M University-Corpus Christi Organized Research Grant
Publications
- Arvidson, C.G., Larson, J.A., Stella, K.K., Waldbeser, L.S., O'Gaora, P. and So, M. Identification and characterization of gly1, a PilA-regulated locus of Neisseria gonorrhoeae (Submitted for publication)
- Waldbeser, L. S., Chen, Q. and Crosa, J. H. (1995) Antisense RNA regulation of fatB iron transport gene in Vibrio anguillarum. Mol. Microbiol. 17:747-756.
- Waldbeser, L. S., Ajioka, R. S., Merz, A. J., Puaoi, D., Lin, L., Thomas, M. and So, M. (1994) The opaH locus of Neisseria gonorrhoeae strain MS11A is involved in epithelial cell invasion. Mol. Microbiol. 13:919-928.
- Waldbeser, L. S., Tolmasky, M. E., Actis, L. A. and Crosa, J. H. (1993) Mechanisms for negative regulation by iron of the fatA outer membrane gene expression inVibrio anguillarum 775. J. Biol. Chem. 268:10433- 10439.
- Crosa, J. H., Actis, L. A., Salinas, P., Tolmasky, M. E. and Waldbeser, L. S. (1994) Regulation of the iron transport genes encoded by the pJM1 virulence plasmid in Vibrio anguillarum. In C. I. Kado and J. H. Crosa (eds.) Molecular Mechanisms of Bacterial Virulence., Kluwer Academic Publishers, Dordrecht, The Netherlands.
- Salinas, P. C., Waldbeser, L. S. and Crosa, J. H. (1993) Regulation of the expression of bacterial iron transport gene: possible role of an antisense RNA as a repressor. Gene, 123:33-38.
- Koster, W. L., Actis, L. A., Waldbeser, L. S., Tolmasky, M. E., and Crosa, J. H. (1991) Molecular characterization of the iron transport system mediated by the pJM1 plasmid in Vibrio anguillarum 775. J. Biol. Chem. 266:23829- 23833.
- Malley, A., Stewart, C. C., Stewart, S. J., Waldbeser, L., Bradley, L. M., and Shiigi, S. M. (1988) Flow cytometric analysis of I-J expression on murine bone marrow-derived macrophages. J. Leukocyte Biol. 43:557- 565.
- Prince, H. E., Kreiss, J. K., Kasper, C. K., Kleinman, S., Saunders, A. M., Waldbeser, L., Mandigo, G. and Kaplan, H. S. (1985) Distinctive lymphocyte subpopulation abnormalities in patients with congenital coagulation disorders who exhibit lymph node enlargement. Blood, 66:64- 68.
- Prince, H. E., Hirji, K., Waldbeser, L., Plaeger-Marshall, S., Kleinman, S., and Lanier, L. (1985) Influence of racial background on the distribdtion of T cell subsets and Leu 11-positive lymphocytes in healthy blood Donors. Diagnostic Immunology, 3:33-37
|
